CD27 Antibody#23578,Cell Signaling Technology (CST),23578

CD27 (TNFRSF7) is a transmembrane protein of the TNF receptor superfamily (TNFRSF). It is mainly expressed on lymphoid cells (also on early hematopoietic precursor cells in mice) (1,2). CD27 is considered a phenotypic marker for memory B cells and is also used to identify B regulatory (Breg) cells (3,4). It is constitutively expressed on naïve CD4 and CD8 T cells, and its expression is further upregulated upon T cell activation. CD27 is one of the two most important co-stimulatory receptors for T cell priming (the other one is CD28). While CD28 co-stimulatory signal mainly triggers cell proliferation, CD27 co-stimulatory signal primarily promotes cell survival and differentiation (5,6). Upon binding to its ligand CD70, CD27 activates the NF-κB and JNK signaling pathways through TNFR-associated factors (TRAFs), the adaptor molecules that are associated with CD27 cytoplasmic tail domain. Upon activation, CD27 is shed from the cell surface, and soluble CD27 is used as a marker of T cell activation (7,8).So, T. et al. (2006)Int J Hematol83, 1-11.Waight, J.D. et al. (2017)Hum Antibodies25, 87-109.Agematsu, K. (2000)Histol Histopathol15, 573-6.Bouaziz, J.D. et al. (2012)Curr Mol Med12, 519-27.Croft, M.Cytokine Growth Factor Rev14, 265-73.Acuto, O. and Michel, F. (2003)Nat Rev Immunol3, 939-51.Lens, S.M. et al. (1998)Semin Immunol10, 491-9.van de Ven, K. and Borst, J. (2015)Immunotherapy7, 655-67.Alternate NamesCD antigen 27; Cd27; CD27 antigen; CD27L receptor; OTTMUSP00000029268; OTTMUSP00000029269; S15; S152; T-cell activation antigen CD27; Tnfr; Tnfrsf7; Tp5; Tp55; Tumor necrosis factor receptor superfamily member 7; tumor necrosis factor receptor superfamily, member 7

CD antigen 27; Cd27; CD27 antigen; CD27L receptor; OTTMUSP00000029268; OTTMUSP00000029269; S15; S152; T-cell activation antigen CD27; Tnfr; Tnfrsf7; Tp5; Tp55; Tumor necrosis factor receptor superfamily member 7; tumor necrosis factor receptor superfamily, member 7