CD3 epsilon (D4V8L) Rabbit Monoclonal Antibody#99940,Cell Signaling Technology (CST),99940

When T cells encounter antigens via the T cell receptor (TCR), information about the quantity and quality of antigens is relayed to the intracellular signal transduction machinery (1). This activation process depends mainly on CD3 (Cluster of Differentiation 3), a multiunit protein complex that directly associates with the TCR. CD3 is composed of four polypeptides: ζ, γ, ε, and δ. Each of these polypeptides contains at least one immunoreceptor tyrosine-based activation motif (ITAM) (2). Engagement of the TCR complex with foreign antigens induces tyrosine phosphorylation in the ITAM motifs and phosphorylated ITAMs function as docking sites for signaling molecules such as ZAP-70 and the p85 subunit of PI-3 kinase (3,4). TCR ligation also induces a conformational change in CD3ε, such that a proline region is exposed and then associates with the adaptor protein Nck (5).Kuhns, M.S. et al. (2006)Immunity24, 133-139.Pitcher, L.A. and van Oers, N.S. (2003)Trends Immunol.24, 554-560.Osman, N. et al. (1996)Eur. J. Immunol.26, 1063-1068.Hatada, M.H. et al. (1995)Nature377, 32-38.Gil, D. et al. (2002)Cell109, 901-912.Alternate NamesAI504783; CD3; CD3 antigen, epsilon polypeptide; Cd3e; CD3epsilon; OTTMUSP00000018104; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain; T3e

AI504783; CD3; CD3 antigen, epsilon polypeptide; Cd3e; CD3epsilon; OTTMUSP00000018104; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain; T3e