CD31 Antibody (YA541),MedChemexpress,HY-P80447

CD31 is a cell adhesion molecule essential for leukocyte transendothelial migration (TEM) under inflammatory conditions. Its Tyr-690 residue critically regulates TEM by facilitating PECAM1 trafficking to/from the lateral border recycling compartment (LBRC) and directing LBRC membrane targeting around migrating leukocytes. CD31 mediates endothelial cell-cell adhesion via homophilic interactions and promotes neutrophil TEM through heterophilic binding with CD177. Homophilic ligation transmits a detachment signal to prevent phagocytosis of viable leukocytes by macrophages, while tethering apoptotic leukocytes to phagocytes (the detachment signal is disabled in apoptosis). It modulates BDKRB2 activation and regulates bradykinin/hyperosmotic shock-induced ERK1/2 signaling in endothelial cells (By similarity: may confer atherosclerosis susceptibility but lacks anti-apoptotic protection).

Adhesion molecule antibody; CD31 antibody; CD31 antigen antibody; CD31 EndoCAM antibody; EndoCAM antibody; FLJ34100 antibody; FLJ58394 antibody; GPIIA antibody; GPIIA' antibody; PECA1 antibody; PECA1_HUMAN antibody; Pecam 1 antibody; PECAM 1 CD31 EndoCAM antibody; PECAM antibody; PECAM-1 antibody; Pecam1 antibody; Platelet and endothelial cell adhesion molecule 1 antibody; Platelet endothelial cell adhesion molecule antibody; Platelet/endothelial cell adhesion molecule 1 antibody;