CD31 (PECAM-1) (89C2) Mouse Monoclonal Antibody (Alexa Fluor®488 Conjugate)#42777,Cell Signaling Technology (CST),42777

CD31 (PECAM-1) (89C2) Mouse Monoclonal Antibody (Alexa Fluor®488 Conjugate) detects endogenous levels of total CD31 protein. This antibody conjugate does not cross-react with other related proteins.

Host

Mouse

Reactivity

Human

Application

Immunohistochemistry (Paraffin): 1:100 - 1:400 Immunofluorescence (Immunocytochemistry): 1:200 - 1:800

Platform ID

BAB255355515

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameCD31 (PECAM-1) (89C2) Mouse Monoclonal Antibody (Alexa Fluor®488 Conjugate)#42777
Cat. No.42777
Accession NumberP16284
Gene ID (Entrez)16284, 5175
HostMouse
SensitivityEndogenous
ReactivityHuman
ApplicationImmunohistochemistry (Paraffin): 1:100 - 1:400 Immunofluorescence (Immunocytochemistry): 1:200 - 1:800
ImmunogenIgG1
FormulationSupplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/ml BSA. Store at 4°C.Do not aliquot the antibody. Protect from light. Do not freeze.
StorageSupplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/ml BSA. Store at 4°C.Do not aliquot the antibody. Protect from light. Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD31 (Platelet Endothelial Cell Adhesion Molecule-1: PECAM-1), a member of the Ig superfamily of cell adhesion molecules, is expressed by circulating platelets, monocytes, neutrophils, some T cells, and endothelial cells and modulates cell adhesion, endothelial cell migration, and angiogenesis (1). CD31 is phosphorylated on Tyr686 at the cytoplasmic carboxy-terminal tail upon various stimuli (e.g. mechanical or oxidative stress), presumably by Src family members (2). The tyrosine phosphorylation mediates associations with a number of SH2 domain-containing binding partners such as PI3 kinase, SHIP, PLCγ, and SHP-2. Thus, CD31 serves as a scaffold for various signaling molecules (3).Newman, P.J. (1997)J. Clin. Invest.99, 3-8.Cao, M. Y. et al. (1998)J. Biol. Chem.273, 15765-72.Ilan, N. and Madri, J.A. (2003)Curr. Opin. Cell Biol.15, 515-24.Alternate Namesadhesion molecule; CD31; CD31 antigen; CD31/EndoCAM; EndoCAM; FLJ58394; GPIIA'; PECA1; PECAM-1; PECAM-1, CD31/EndoCAM; PECAM1; platelet and endothelial cell adhesion molecule 1; Platelet endothelial cell adhesion molecule; platelet endothelial cell adhesion molecule-1; platelet/endothelial cell adhesion molecule

Synonyms

adhesion molecule; CD31; CD31 antigen; CD31/EndoCAM; EndoCAM; FLJ58394; GPIIA'; PECA1; PECAM-1; PECAM-1, CD31/EndoCAM; PECAM1; platelet and endothelial cell adhesion molecule 1; Platelet endothelial cell adhesion molecule; platelet endothelial cell adhesion molecule-1; platelet/endothelial cell adhesion molecule

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