CD38 (E7Z8C) Rabbit Monoclonal Antibody#51000,Cell Signaling Technology (CST),51000

Cyclic ADP-ribose hydrolase 1 (CD38) is a transmembrane protein involved in several important biological processes, including immune response, insulin secretion, and social behavior. Originally described as a glycosylated immune cell surface marker, additional research determined that CD38 is a multifunctional enzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD (1,2). Under acidic conditions, CD38 also catalyzes the synthesis of nicotinic acid adenine dinucleotide phosphate (NAADP) from NADP+. Both cADPR and NAADP act as calcium ion mobilizing messengers that target different intracellular Ca2+stores (3-6). Since CD38 is the primary mammalian NAD+glycohydrolase responsible for NAD+metabolism, CD38 may be a valuable therapeutic target for treatment of metabolic diseases regulated by NAD+-dependent pathways (7,8). CD38 has also been considered a possible therapeutic target for antibody-mediated therapy for myeloma and chronic lymphocytic leukemia (9-11).Malavasi, F. et al. (2008)Physiol Rev88, 841-86.Jin, D. et al. (2007)Nature446, 41-5.Lee, H.C. et al. (1999)Mol Cell Biochem193, 89-98.Calcraft, P.J. et al. (2009)Nature459, 596-600.Ogunbayo, O.A. et al. (2011)J Biol Chem286, 9136-40.Lee, H.C. (2012)J Biol Chem287, 31633-40.Cantó, C. et al. (2012)Cell Metab15, 838-47.Escande, C. et al. (2013)Diabetes62, 1084-93.Malavasi, F. et al. (2011)Blood118, 3470-8.Deaglio, S. et al. (2010)Semin Cancer Biol20, 416-23.Chillemi, A. et al. (2013)Mol Med19, 99-108.Alternate Names2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; ADPRC 1; ADPRC1; cADPr hydrolase 1; CD38; CD38 antigen (p45); CD38 molecule; cluster of differentiation 38; Cyclic ADP-ribose hydrolase 1; ecto-nicotinamide adenine dinucleotide glycohydrolase; NAD(+) nucleosidase; T10

2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; ADPRC 1; ADPRC1; cADPr hydrolase 1; CD38; CD38 antigen (p45); CD38 molecule; cluster of differentiation 38; Cyclic ADP-ribose hydrolase 1; ecto-nicotinamide adenine dinucleotide glycohydrolase; NAD(+) nucleosidase; T10