CD38 (E9F5A) Rabbit Monoclonal Antibody (Alexa Fluor®488 Conjugate)#46764,Cell Signaling Technology (CST),46764

CD38 (E9F5A) Rabbit Monoclonal Antibody (Alexa Fluor®488 Conjugate) recognizes endogenous levels of total CD38 protein.

Host

Rabbit

Reactivity

Mouse, Rat

Application

Immunohistochemistry (Paraffin): 1:50 - 1:200

Platform ID

BAB192974208

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameCD38 (E9F5A) Rabbit Monoclonal Antibody (Alexa Fluor®488 Conjugate)#46764
Cat. No.46764
Accession NumberP56528
Gene ID (Entrez)56528, 12494
HostRabbit
SensitivityEndogenous
ReactivityMouse, Rat
ApplicationImmunohistochemistry (Paraffin): 1:50 - 1:200
ImmunogenIgG
FormulationSupplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C.Do not aliquot the antibody. Protect from light. Do not freeze.
StorageSupplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C.Do not aliquot the antibody. Protect from light. Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

Cyclic ADP-ribose hydrolase 1 (CD38) is a transmembrane protein involved in several important biological processes, including immune response, insulin secretion, and social behavior. Originally described as a glycosylated immune cell surface marker, additional research determined that CD38 is a multifunctional enzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD (1,2). Under acidic conditions, CD38 also catalyzes the synthesis of nicotinic acid adenine dinucleotide phosphate (NAADP) from NADP+. Both cADPR and NAADP act as calcium ion mobilizing messengers that target different intracellular Ca2+stores (3-6). Since CD38 is the primary mammalian NAD+glycohydrolase responsible for NAD+metabolism, CD38 may be a valuable therapeutic target for treatment of metabolic diseases regulated by NAD+-dependent pathways (7,8). CD38 has also been considered a possible therapeutic target for antibody-mediated therapy for myeloma and chronic lymphocytic leukemia (9-11).Malavasi, F. et al. (2008)Physiol Rev88, 841-86.Jin, D. et al. (2007)Nature446, 41-5.Lee, H.C. et al. (1999)Mol Cell Biochem193, 89-98.Calcraft, P.J. et al. (2009)Nature459, 596-600.Ogunbayo, O.A. et al. (2011)J Biol Chem286, 9136-40.Lee, H.C. (2012)J Biol Chem287, 31633-40.Cantó, C. et al. (2012)Cell Metab15, 838-47.Escande, C. et al. (2013)Diabetes62, 1084-93.Malavasi, F. et al. (2011)Blood118, 3470-8.Deaglio, S. et al. (2010)Semin Cancer Biol20, 416-23.Chillemi, A. et al. (2013)Mol Med19, 99-108.Alternate Names2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; ADPRC 1; cADPr hydrolase 1; Cd38; CD38 antigen; Cd38-r; Cd38-rs1; Cyclic ADP-ribose hydrolase 1; I-19; NIM-R5 antigen

Synonyms

2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; ADPRC 1; cADPr hydrolase 1; Cd38; CD38 antigen; Cd38-r; Cd38-rs1; Cyclic ADP-ribose hydrolase 1; I-19; NIM-R5 antigen

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