CD4 Antibody (YA537),MedChemexpress,HY-P80055
CD4 Antibody (YA537) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD4.
Host
Rabbit
Reactivity
Human
Application
WB,IHC-P,ICC/IF,FC,IF-Tissue,mIHC
Conjugate
Non-conjugated
Platform ID
BAB128654293
Suppliers
(1)Biomedical Life sciences
MedChemexpress
Master of Bioactive Molecules
Contact
Tel: 609-228-6898
Fax: 609-228-5909
Email:
Specifications
Verification Image
Scientific Background
CD4 protein forms disulfide-linked homodimers at the cell surface and interacts with various proteins, including LCK, PTK2/FAK1, and P4HB/PDI. It also engages with IL16, leading to CD4-dependent signaling in lymphocytes. Furthermore, CD4 interacts with MHCII alpha and beta chains, enhancing the affinity of the T-cell receptor (TCR) for peptide-MHCII. The oligomerization of CD4, particularly via Ig-like C2-type domains 2 and 3, is crucial for stable binding to MHCII and facilitates adhesion between T cells and antigen-presenting cells (APCs).
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
- Products>Primary Antibodies>IHC Antibodies
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