CD69 (F8N6A) Rabbit Monoclonal Antibody#72240,Cell Signaling Technology (CST),72240

CD69, also known as Leu-23, is a type II transmembrane glycoprotein that is expressed on the surface of T cells, B cells, and NK cells (1,2). This phosphorylated disulfide-linked 28 to 32-kDa homodimer is constitutively expressed on a subset of thymocytes and platelets. It also acts as an activation antigen of lymphocytes, NK cells, neutrophils, and eosinophils (1-6). Studies have shown that stimulation of the T cell receptor (TCR) increases the expression of CD69 on the cell surface. The ability to detect the level of CD69 expression after TCR activation makes CD69 an ideal indicator of T cell activation (1).ÂTesti, R. et al. (1989)J Immunol142, 1854-60.Marzio, R. et al. (1997)J Leukoc Biol62, 349-55.Lanier, L.L. et al. (1988)J Exp Med167, 1572-85.Testi, R. et al. (1988)J Immunol141, 2557-63.Hartnell, A. et al. (1993)Immunology80, 281-6.Gavioli, R. et al. (1992)Cell Immunol142, 186-96.Alternate Names5830438K24Rik; AI452015; AIM; Cd69; CD69 antigen; Early activation antigen CD69; VEA; Very Early Activation Antigen

5830438K24Rik; AI452015; AIM; Cd69; CD69 antigen; Early activation antigen CD69; VEA; Very Early Activation Antigen