CD9 (E3O1B) Rabbit Monoclonal Antibody#99950,Cell Signaling Technology (CST),99950

CD9 (E3O1B) Rabbit Monoclonal Antibody recognizes endogenous levels of total CD9 protein.

Host

Rabbit

Reactivity

Human

Application

Western Blotting: 1:1000 Simple WesternTM: 1:10 - 1:50 Flow Cytometry (Live): 1:100 - 1:400

Platform ID

BAB657330061

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameCD9 (E3O1B) Rabbit Monoclonal Antibody#99950
Cat. No.99950
Accession NumberP21926
Gene ID (Entrez)21926
HostRabbit
SensitivityEndogenous
ReactivityHuman
ApplicationWestern Blotting: 1:1000 Simple WesternTM: 1:10 - 1:50 Flow Cytometry (Live): 1:100 - 1:400
Molecular Weight22-27
ImmunogenIgG
FormulationSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C.Do not aliquot the antibody.For a carrier free (BSA and azide free) version of this product see product #70559.
StorageSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C.Do not aliquot the antibody.For a carrier free (BSA and azide free) version of this product see product #70559.
Regulatory StatusResearch Use Only

Scientific Background

The CD9 antigen belongs to the tetraspanin family of cell surface glycoproteins, and is characterized by four transmembrane domains, one short extracellular domain (ECL1), and one long extracellular domain (ECL2). Tetraspanins interact with a variety of cell surface proteins and intracellular signaling molecules in specialized tetraspanin-enriched microdomains (TEMs), where they mediate a range of processes including adhesion, motility, membrane organization, and signal transduction (1). Research studies demonstrate that CD9 expression on the egg is required for gamete fusion during fertilization (2-4). CD9 was also shown to play a role in dendritic cell migration, megakaryocyte differentiation, and homing of cord blood CD34+ hematopoietic progenitors to the bone marrow (5-7). In addition, downregulation of CD9 expression is associated with poor prognosis and progression of several types of cancer (8-10). Additional research identified CD9 as an abundant component of exosomes, and may play some role in the fusion of these secreted membrane vesicles with recipient cells (11).Hemler, M.E. (2005)Nat Rev Mol Cell Biol6, 801-11.Le Naour, F. et al. (2000)Science287, 319-21.Miyado, K. et al. (2000)Science287, 321-4.Kaji, K. et al. (2000)Nat Genet24, 279-82.Mantegazza, A.R. et al. (2004)Blood104, 1183-90.Clay, D. et al. (2001)Blood97, 1982-9.Leung, K.T. et al. (2011)Blood117, 1840-50.Miyake, M. et al. (1995)Cancer Res55, 4127-31.Higashiyama, M. et al. (1995)Cancer Res55, 6040-4.Uchida, S. et al. (1999)Br J Cancer79, 1168-73.Théry, C. et al. (1999)J Cell Biol147, 599-610.Alternate Names5H9 antigen; antigen CD9; BA-2/p24 antigen; BTCC-1; CD9; CD9 antigen; CD9 antigen (p24); CD9 molecule; Cell growth-inhibiting gene 2 protein; DRAP-27; Leukocyte antigen MIC3; MIC3; motility related protein-1; Motility-related protein; MRP-1; p24; Tetraspanin-29; Tspan-29; TSPAN29

Synonyms

5H9 antigen; antigen CD9; BA-2/p24 antigen; BTCC-1; CD9; CD9 antigen; CD9 antigen (p24); CD9 molecule; Cell growth-inhibiting gene 2 protein; DRAP-27; Leukocyte antigen MIC3; MIC3; motility related protein-1; Motility-related protein; MRP-1; p24; Tetraspanin-29; Tspan-29; TSPAN29

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