CDKN2B/p15 INK4b Polyclonal Antibody,Bioss,bs-4269r

Host

Rabbit

Reactivity

Human, Mouse, Rat, Bovine, Dog, Chicken

Application

WB, IHC-P, IF(IHC-P)

Conjugate

Unconjugated

Platform ID

BAB557542809

Bioss

Headquarters

300 Tradecenter Dr, ste 4610Woburn, Massachusetts 01801 - U.S.A.

Bioss

Contact

Tel: +1.781.569.5821
Fax: +1.781.731.9286

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameCDKN2B/p15 INK4b Polyclonal Antibody
Cat. No.bs-4269r
Accession NumberP42772
Gene ID (Entrez)1030
HostRabbit
IsotypeIgG
ReactivityHuman, Mouse, Rat, Bovine, Dog, Chicken
ConjugationUnconjugated
ApplicationWB, IHC-P, IF(IHC-P)
Working DilutionsWB:1:300-5000 | IHC-P:1:200-400 | IF(IHC-P):1:50-200
ClonalityPolyclonal
Concentration1ug/ul
PurityPurified by Protein A.
Formulation0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
StorageStore at -20C for 12 months.

Scientific Background

p15 INK4b / MTS 2 (Mitotic Inhibitor / Suppressor Protein) is a specific inhibitor of cdk 4 / cdk 6 and is periodically expressed during the cell cycle. Reportedly, p15 INK4b expression is induced approximately 30 fold in human keratinocytes by treatment with TGF beta, suggesting that p15 INK4b may act as an effector of TGF beta mediated cell cycle arrest. p15 INK4b is mapped to chromosome 9p21, a region of frequent loss in a wide variety of cancers.

Synonyms

CDK inhibitory protein; CDK4B Inhibitor; CDKN2B; Cyclin dependent kinase 4 inhibitor B; Cyclin Dependent Kinase Inhibitor 2B; Cyclin dependent kinase inhibitor 2B p15 inhibits CDK4; Cyclin-dependent kinases 4 and 6 binding protein; INK4B; MTS 2; MTS2; Multiple Tumor Supressor 2; p14 CDK inhibitor; p14 INK4b; P15; p15 CDK inhibitor; p15 inhibits CDK4; p15 INK4b; P15INK4B; p15INK4B; TP 15; TP15.

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