CLEC2 Antibody (YA4540)(PBS only),MedChemexpress,HY-P84843A

CLEC2 Antibody (YA4540) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to CLEC2.

Host

Mouse

Reactivity

Human

Application

IHC-P,FC,ELISA

Conjugate

Non-conjugated

Platform ID

BAB015874660

Suppliers

(1)

Biomedical Life sciences

91-9676853503

[email protected]
Country:India
City:Madīnat Ḩamad
Plot No.A-2811121/A&B/3.IP NACHARAM. ALA NACHARAM, Road N0-15, Hyderabad Medchal Malkajgiri, Telangana-500076
Master of Bioactive Molecules

MedChemexpress

Master of Bioactive Molecules

Headquarters

1 Deer Park Drive, Suite FMONMOUTH JUNCTION, NI 08852, USA

MedChemexpress

Contact

Tel: 609-228-6898
Fax: 609-228-5909

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameCLEC2 Antibody (YA4540)(PBS only)
Cat. No.HY-P84843A
Accession NumberQ9P126
Gene ID (Entrez)51266
HostMouse
IsotypeIgG2a
ReactivityHuman
ConjugationNon-conjugated
ApplicationIHC-P,FC,ELISA
Working DilutionsIHC-P: 1:200-1:1000; FC: 1:200-1:400; ELISA: 1:10000
Clone NumberYA4540
Molecular WeightPredicted band size: 26.6 kDa; Observed band size: 25 kDa
ImmunogenPurified recombinant fragment of human CLEC2 (AA: Extra(58-229)) expressed in E. Coli.
Purityaffinity purified.
Appearance/FormLiquid
ShippingShipping with blue ice.
FormulationSupplied in PBS, pH 7.4.
StorageStored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

CLEC2 is a C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker PDPN. Upon ligand activation, it signals via sequential activation of SRC and SYK tyrosine kinases, leading to PLCG2 activation. In microbial infections, CLEC2 acts as a receptor for the snake venom protein rhodocytin, triggering tyrosine phosphorylation and SYK binding, which initiates downstream phosphorylation events and PLCG2 activation. Additionally, CLEC2 serves as an attachment factor for Human immunodeficiency virus type 1 (HIV-1), facilitating its capture by platelets.

Synonyms

CLEC2; CLEC2B; PRO1384; QDED721; 1810061I13Rik

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