COL1A1 (E3E1X) Mouse Monoclonal Antibody#66948,Cell Signaling Technology (CST),66948

Type 1 collagen is the most abundant collagen in many human tissues, including bone, skin, and tendons. It is a trimeric complex composed of two molecules of COL1A1 (alpha-1 type 1 collagen) and one molecule of COL1A2 (alpha-2 type 1 collagen) (1-3). The expression levels of COL1A1 are regulated by multiple mechanisms, including mRNA stability, translation, and post-translational modification (3-5). Overexpression of COL1A1 has been positively associated with tissue fibrosis disorders, including systemic sclerosis (6), while loss-of-function mutations in theCOL1A1gene are a major causative factor for osteogenesis imperfecta (brittle bone disease) (7). Notably, COL1A1 expression levels have also been associated with tumor development in gastric, lung, thyroid, and breast cancers. Research studies suggest that upregulation of COL1A1 can generate a modified extracellular matrix environment that promotes cancer cell survival, proliferation, metastasis, and invasion (8-11).Prockop, D.J. and Kivirikko, K.I. (1995)Annu Rev Biochem64, 403-34.Chang, S.W. et al. (2012)Biophys J102, 640-8.Zhang, Y. and Stefanovic, B. (2016)Int J Mol Sci17, 419.Parsons, C.J. et al. (2011)J Biol Chem286, 8609-19.Cai, L. et al. (2010)J Mol Biol395, 309-26.Jimenez, S.A. and Saitta, B. (1999)Springer Semin Immunopathol21, 397-414.Forlino, A. et al. (2011)Nat Rev Endocrinol7, 540-57.Li, J. et al. (2016)World J Surg Oncol14, 297.Oleksiewicz, U. et al. (2017) J Cancer Res Clin Oncol 143, 1133-41.Barcus, C.E. et al. (2017)Breast Cancer Res19, 9.Jolly, L.A. et al. (2016)Cancer Res76, 1804-13.Alternate NamesAlpha-1 type I collagen; alpha1(I) procollagen; CAFYD; CO1A1; COL1A1; collagen 1; collagen alpha 1 chain type I; Collagen alpha-1(I) chain; collagen alpha-1(I) chain preproprotein; collagen I; collagen of skin, tendon and bone, alpha-1 chain; collagen type I; collagen type I alpha 1 chain; collagen, type I, alpha 1; EDSARTH1; EDSC; OI1; OI2; OI3; OI4; pro-alpha-1 collagen type 1; type I collagen; type I proalpha 1; type I procollagen alpha 1 chain

Alpha-1 type I collagen; alpha1(I) procollagen; CAFYD; CO1A1; COL1A1; collagen 1; collagen alpha 1 chain type I; Collagen alpha-1(I) chain; collagen alpha-1(I) chain preproprotein; collagen I; collagen of skin, tendon and bone, alpha-1 chain; collagen type I; collagen type I alpha 1 chain; collagen, type I, alpha 1; EDSARTH1; EDSC; OI1; OI2; OI3; OI4; pro-alpha-1 collagen type 1; type I collagen; type I proalpha 1; type I procollagen alpha 1 chain