COL4A1 (E9T4L) Rabbit Monoclonal Antibody#31882,Cell Signaling Technology (CST),31882

COL4A1 (E9T4L) Rabbit Monoclonal Antibody recognizes endogenous levels of total COL4A1 protein. This antibody also cross-reacts with bands at 30 kDa and 60 kDa of unknown origin.

Host

Rabbit

Reactivity

Human, Mouse, Rat

Application

Western Blotting: 1:1000

Platform ID

BAB409204161

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameCOL4A1 (E9T4L) Rabbit Monoclonal Antibody#31882
Cat. No.31882
Accession NumberP02463
Gene ID (Entrez)02463, 12826
HostRabbit
SensitivityEndogenous
ReactivityHuman, Mouse, Rat
ApplicationWestern Blotting: 1:1000
Molecular Weight200, 220
ImmunogenIgG
FormulationSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C.Do not aliquot the antibody.
StorageSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C.Do not aliquot the antibody.
Regulatory StatusResearch Use Only

Scientific Background

Type IV collagens support extracellular matrix (ECM) function by forming a cross-linking network in the basement membrane zone. There are six different type IV collagens that are encoded by the following genes:COL4A1,COL4A2,COL4A3,COL4A4,COL4A5, andCOL4A6. Among them, COL4A1 and COL4A2 are the most common collagens found in the basement membrane, and are usually used as a marker of the basement membrane dynamic stability (1). The type IV collagen fiber exists as a trimeric complex composed of two molecules of COL4A1 and one molecule of COL4A2. The N-terminal 7S domains of the protein function on intermolecular cross-linking, and C-terminal non-collagenous domains (NCI) are responsible for heterotrimer assembly. The trimeric fiber further associates to form a cross-linked sheet structure by NCI/NCI and 7S/7S interaction (2). COL4A1 plays a critical role in maintaining basement membrane integrity for normal tissue functions. Genetic mutations of COL4A1 and COL4A2 have been linked to cardiovascular disease, cerebral small vessel disease, and glomerulocystic kidney disease (3-5).Jeanne, M. and Gould, D.B. (2017)Matrix Biol57-8, 29-44.Kuo, D.S. et al. (2012)Hum Mol Genet21, R97-110.Steffensen, L.B. and Rasmussen, L.M. (2018)Am J Physiol Heart Circ Physiol315, H610-H625.Giau, V.V. et al. (2019)Int J Mol Sci20, pii: E4298. doi: 10.3390/ijms20174298.Chen, Z. et al. (2016)J Am Soc Nephrol27, 1042-54.Alternate Namesalpha-1 type IV collagen; alpha1(IV) collagen; Arresten; Bru; CO4A1; Col4; Col4a-1; Col4a1; Collagen alpha-1(IV) chain; collagen, type IV, alpha 1; Del(8)44; Del(8)44H; Del(8)Bru44H; OTTMUSP00000023605; procollagen, type IV, alpha 1; Raw; retinal anterior wiring; Svc

Synonyms

alpha-1 type IV collagen; alpha1(IV) collagen; Arresten; Bru; CO4A1; Col4; Col4a-1; Col4a1; Collagen alpha-1(IV) chain; collagen, type IV, alpha 1; Del(8)44; Del(8)44H; Del(8)Bru44H; OTTMUSP00000023605; procollagen, type IV, alpha 1; Raw; retinal anterior wiring; Svc

Category Paths

Request a product

Please provide the required information below so that we can quickly source your products.