COX1/MT-CO1 Antibody#62101,Cell Signaling Technology (CST),62101

COX1/MT-CO1 Antibody recognizes endogenous levels of total COX1/MT-CO1 protein. This antibody does not cross-react with COX2/MT-CO2 protein or COX3/MT-CO3 protein.

Reactivity

Human, Mouse, Rat, Monkey

Application

Western Blotting: 1:1000

Platform ID

BAB971935300

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameCOX1/MT-CO1 Antibody#62101
Cat. No.62101
Accession NumberP00395
Gene ID (Entrez)00395, 4512
SensitivityEndogenous
ReactivityHuman, Mouse, Rat, Monkey
ApplicationWestern Blotting: 1:1000
Molecular Weight32
FormulationSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C.Do not aliquot the antibody.
StorageSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C.Do not aliquot the antibody.
Regulatory StatusResearch Use Only

Scientific Background

The mitochondrial electron transport chain comprises multiple protein complexes including cytochrome c oxidase. Cytochrome c oxidase catalyzes the reduction of oxygen to water. This process is coupled with pumping protons from the mitochondrial matrix into mitochondrial intermembrane space, contributing to the proton gradient used for ATP synthesis (1). Cytochrome c oxidase consists of 3 mitochondrial DNA-encoded subunits (COX1/MT-CO1, COX2/MT-CO2, and COX3/MT-CO3) and multiple nuclear DNA-encoded subunits (2). Research studies show that the mRNAs of the mitochondrially encoded oxidative phosphorylation subunits, including COX1/MT-CO1, decline significantly during aging (3).Nolfi-Donegan, D. et al. (2020)Redox Biol37, 101674.Zong, S. et al. (2018)Cell Res28, 1026-1034.Gomes, A.P. et al. (2013)Cell155, 1624-38.Alternate NamesCOI; COX1; COXI; cytochrome C oxidase; Cytochrome c oxidase polypeptide I; Cytochrome c oxidase subunit 1; cytochrome c oxidase subunit I; mitochondrially encoded cytochrome c oxidase I; MT-CO1; MT-COI; MTCO1

Synonyms

COI; COX1; COXI; cytochrome C oxidase; Cytochrome c oxidase polypeptide I; Cytochrome c oxidase subunit 1; cytochrome c oxidase subunit I; mitochondrially encoded cytochrome c oxidase I; MT-CO1; MT-COI; MTCO1

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