CR1/CD35 (E8B1Z) Rabbit Monoclonal Antibody#96615,Cell Signaling Technology (CST),96615

Complement receptor type 1 (CR1/CD35) is a type I transmembrane glycoprotein that is expressed on the surface of B cells, neutrophils, monocytes, and renal podocytes (1,2). As a component of the host innate immune system, CR1/CD35 expressed on neutrophils and monocytes binds to ligands coated with the complement opsonins, C3b and C4b, which facilitates phagocytosis and production of proinflammatory cytokines (3,4). CR1/CD35 also participates in negative regulation of the complement cascade through its ability to promote dissociation of C3 and C5 convertases (4,5) and by serving as one of multiple cofactors for factor-I-mediated cleavage and inactivation of C3b and C4b (6).Fearon, D.T. (1980)J Exp Med152, 20-30.Tedder, T.F. et al. (1983)J Immunol130, 1668-73.Krych-Goldberg, M. and Atkinson, J.P. (2001)Immunol Rev180, 112-22.Bacle, F. et al. (1990)J Immunol144, 147-52.Hourcade, D.E. et al. (2002)J Biol Chem277, 1107-12.Masaki, T. et al. (1992)J Biochem111, 573-8.Alternate NamesC3-binding protein; C3b/C4b receptor; C3BR; C4BR; CD35; CD35 antigen; complement C3b/C4b receptor 1 (Knops blood group); complement component (3b/4b) receptor 1 (Knops blood group); complement component receptor 1; complement receptor 1; Complement receptor type 1; CR1; KN; Knops blood group antigen

C3-binding protein; C3b/C4b receptor; C3BR; C4BR; CD35; CD35 antigen; complement C3b/C4b receptor 1 (Knops blood group); complement component (3b/4b) receptor 1 (Knops blood group); complement component receptor 1; complement receptor 1; Complement receptor type 1; CR1; KN; Knops blood group antigen