CRISP2 antibody,Genetex,GTX85002

Host

Rabbit

Reactivity

Human

Application

WB IHC-P ELISA

Conjugate

Unconjugated

Platform ID

BAB885222000

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameCRISP2 antibody
Cat. No.GTX85002
Gene ID (Entrez)7180
HostRabbit
IsotypeIgG
ReactivityHuman
ConjugationUnconjugated
ApplicationWB IHC-P ELISA
ClonalityPolyclonal
Concentration1 mg/ml (Please refer to the vial label for the specific concentration.)
TargetCRISP2
ImmunogenCRISP2 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human CRISP2.The immunogen is located within the first 50 amino acids of CRISP2.
PurityPurified by antigen-affinity chromatography
Appearance/FormLiquid
FormulationPBS,0.02% Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

The cysteine-rich secretory proteins (CRISP) family is a group of four proteins that are strongly expressed in the male reproductive tract and have been implicated in having roles in male fertility. CRISP2, also known as TPX1, has been implicated in the adhesion between spermatids and Sertoli cells, and with CRISP1, is thought to be involved in sperm-egg fusion. CRISP2 has been shown to regulate the Ca2+ influx through ryanodine receptors (RYR) and may influence the acrosome reaction or sperm motility. CRISP2 has also been shown to bind to the mitogen-activated protein kinase kinase kinase 11 (MAP3K11) and localizes to the developing acrosome, suggesting this CRISP2-MAP3K11 complex may have a role in acrosome development.

Synonyms

cysteine rich secretory protein 2 , CRISP-2 , CT36 , GAPDL5 , TPX1 , TSP1

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