CTLA4 antibody [BNI3] (APC),Genetex,GTX00492-07

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]

ALPS5 , CD , CD152 , CELIAC3 , CTLA4 , GRD4 , GSE , IDDM12 , cytotoxic Tlymphocyte associated protein 4 , cytotoxic T-lymphocyte associated protein 4