CTPS1 (E7M3Q) Rabbit Monoclonal Antibody#31810,Cell Signaling Technology (CST),31810

CTPS1 (cytidine triphosphate synthase 1 or CTP synthase 1) catalyzes the conversion of UTP to CTP through ATP-dependent amination (1). Research studies show that pyrimidine biosynthesis is upregulated in pancreatic cancer cell models of resistance to gemcitabine, a deoxycytidine analog. Increased pyrimidine biosynthesis leads to elevated levels of endogenous dCTP, which outcompetes gemcitabine from incorporating into DNA during replication and, therefore, reduces the anti-cancer effectiveness of gemcitabine. Induction ofCTPS1expression was observed in gemcitabine-resistant pancreatic cancer cell models. Gemcitabine resistance directly correlates withCTPS1expression levels in various pancreatic cancer cell lines (2). Furthermore, CTPS1 expression was shown to increase in T cells upon T-cell receptor activation, suggesting a critical role of CTPS1 in the immune system (3).McCluskey, G.D. and Bearne, S.L. (2018)FEBS J285, 3724-8.Shukla, S.K. et al. (2017)Cancer Cell32, 71-87.e7.Martin, E. et al. (2014)Nature510, 288-92.Alternate NamesCTP synthase; CTP synthase 1; CTP synthetase 1; CTPS; CTPS1; cytidine 5-prime triphosphate synthetase; cytidine 5'-triphosphate synthetase; GATD5; IMD24; PYRG1; UTP--ammonia ligase 1

CTP synthase; CTP synthase 1; CTP synthetase 1; CTPS; CTPS1; cytidine 5-prime triphosphate synthetase; cytidine 5'-triphosphate synthetase; GATD5; IMD24; PYRG1; UTP--ammonia ligase 1