CXCR4 antibody,Genetex,GTX27199

Host

Rabbit

Reactivity

Mouse, Rat

Application

WB FCM IM

Conjugate

Unconjugated

Platform ID

BAB119577042

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameCXCR4 antibody
Cat. No.GTX27199
HostRabbit
IsotypeIgG
ReactivityMouse, Rat
ConjugationUnconjugated
ApplicationWB FCM IM
ClonalityPolyclonal
Concentration1 mg/ml (Please refer to the vial label for the specific concentration.)
ImmunogenRecombinant full length protein (Rat).
PurityProtein A purified
Appearance/FormLiquid
FormulationPBS,0.1% Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

CXCR4 (fusin) is one of the members in the seven-transmembrane G-protein-coupled chemokine receptor family. The full-length cDNA was isolated from a human spleen cDNA library (ref 1). Its ligand is chemokine stroma-derived factor (SDF). CXCR4 has been proved to be the co-receptor forHIV-2's binding to CD4 through envelope glycoprotein gp 120 (ref 2). In other cases, CXCR4 can even function as the only receptor for HIV-2's binding to the CD4 host cells (ref 3). Mouse monoclonal antibody (12G5) to CXCR4 has been shown to inhibit HIV infectivity and HIV-induced syncytium.

Synonyms

C-X-C Motif Chemokine Receptor 4 , Cxcr4

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