CYP51A1 (F5M4N) Rabbit Monoclonal Antibody#31966,Cell Signaling Technology (CST),31966

CYP51A1 (F5M4N) Rabbit Monoclonal Antibody recognizes endogenous levels of total CYP51A1 protein.

Host

Rabbit

Reactivity

Human, Mouse, Rat

Application

Western Blotting: 1:1000

Platform ID

BAB847972302

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameCYP51A1 (F5M4N) Rabbit Monoclonal Antibody#31966
Cat. No.31966
Accession NumberQ16850
Gene ID (Entrez)16850, 1595
HostRabbit
SensitivityEndogenous
ReactivityHuman, Mouse, Rat
ApplicationWestern Blotting: 1:1000
Molecular Weight57
ImmunogenIgG
FormulationSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C.Do not aliquot the antibody.
StorageSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C.Do not aliquot the antibody.
Regulatory StatusResearch Use Only

Scientific Background

Cytochrome P450 family 51 subfamily A member 1 (CYP51A1), also known as lanosterol 14-alpha demethylase (LDM), is a key endoplasmic reticulum enzyme in cholesterol biosynthesis. Decreased activity of this crucial enzyme impairs liver function, leading to metabolism-associated liver disease and hepatocellular carcinoma (1). Furthermore, studies show that this enzyme, along with several other components in distal cholesterol biosynthesis, is a potential suppressor of ferropotosis (2). Additionally, CYP51A1 was shown to suppress alkalization-induced cell death in a lysosomal pathway in pancreatic cancer cells, demonstrating this enzyme to be a vulnerability in those cells (3).CYP51A1was also identified as a plausible candidate gene for cerebral palsy (CP) (4).Kreft, T. et al. (2026)J Biol Chem302, 111188.Li, Y. et al. (2024)Nature626, 411-418.Chen, F. et al. (2025)Nat Commun16, 2278.Fehlings, D.L. et al. (2024)Nat Genet56, 585-594.Alternate NamesCP51; CP51A; CYP51; CYP51A1; CYPL1; CYPLI; Cytochrome P450 51A1; cytochrome P450 family 51 subfamily A member 1; Cytochrome P450-14DM; cytochrome P450, 51 (lanosterol 14-alpha-demethylase); cytochrome P450, family 51, subfamily A, polypeptide 1; Cytochrome P45014DM; Cytochrome P450LI; Lanosterol 14-alpha demethylase; lanosterol 14-alpha-demethylase; LDM; P450-14DM; P450L1; Sterol 14-alpha demethylase

Synonyms

CP51; CP51A; CYP51; CYP51A1; CYPL1; CYPLI; Cytochrome P450 51A1; cytochrome P450 family 51 subfamily A member 1; Cytochrome P450-14DM; cytochrome P450, 51 (lanosterol 14-alpha-demethylase); cytochrome P450, family 51, subfamily A, polypeptide 1; Cytochrome P45014DM; Cytochrome P450LI; Lanosterol 14-alpha demethylase; lanosterol 14-alpha-demethylase; LDM; P450-14DM; P450L1; Sterol 14-alpha demethylase

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