Ca2+-Activated Cl- Channel Antibody Explorer Kit,Alomone Labs,AK-405_KIT

Anoctamin (ANO, or TMEM16) is a family of 10 membrane proteins. This family is so named because these channels are selective to ANions and have eight (OCT) transmembrane domains. Also, these channels are subject to glycosylation in their extracellular loops and have both intracellular N- and C-termini 1 . Although relatively newly discovered channels, they are being discovered in many medical indications. Ano1 has become a marker in gastrointestinal tumors as its expression is significantly upregulated 2,3 . Similarly, Ano1 is also highly expressed in other carcinomas 4,5 . To date, Bestrophin 1-4 have been identified, although Bestrophin-3 and Bestrophin-4 have been observed only at the RNA level 7 . In addition, splice variants of some of these Ca 2+ -activated Cl - channels (CaCCs) have also been detected 6,8,9 . CaCCs are known to be involved in the regulation of olfaction, taste, phototransduction, and excitability in the nervous system.