CaMKII Antibody (YA4627),MedChemexpress,HY-P84930

CaMKII β is a calcium/calmodulin-dependent protein kinase that operates autonomously following Ca²⁺/calmodulin binding and autophosphorylation, playing roles in dendritic spine/synapse formation, neuronal plasticity, and regulation of sarcoplasmic reticulum Ca²⁺ transport in skeletal muscle. In neurons, it structurally reorganizes the actin cytoskeleton during plasticity by kinase-independent actin filament bundling, enabling proper targeting of CaMK2A to promote synaptic plasticity underlying long-term potentiation (LTP) and hippocampus-dependent learning. It facilitates dendritic arborization in developing hippocampal neurons and remodeling in mature neurons, while also regulating neuronal migration. In skeletal muscle, it modulates function during exercise: regulating SR Ca²⁺ transport in slow-twitch fibers and controlling Ca²⁺ release via phosphorylation of triadin and phospholamban in fast-twitch fibers. Upon IFN-γ stimulation, it phosphorylates STAT1 to activate JAK-STAT signaling (By similarity). Under ER stress, it phosphorylates RETREG1 at Ser-151 to enhance its oligomerization and reticulophagy activity.

Calcium/calmodulin dependent protein kinase II alpha antibody; Calcium/calmodulin dependent protein kinase II beta antibody; Calcium/calmodulin dependent protein kinase II delta antibody; Calcium/calmodulin dependent protein kinase II gamma antibody; Calcium/calmodulin-dependent protein kinase type II subunit alpha antibody; CaM kinase II alpha antibody; CaM kinase II antibody; CaM kinase II beta antibody; CaM kinase II delta antibody; CaM kinase II gamma antibody; CaM kinase II subunit alpha antibody; CaMK-II subunit alpha antibody; CAMK2 antibody; Camk2a antibody; CAMK2B antibody; CAMK2D antibody; CAMK2G antibody; CAMKA antibody; KCC2A_HUMAN antibody; CaMKⅡ