CaMKII alpha (phospho Thr286) antibody [HL3570],Genetex,GTX641517

Host

Rabbit

Reactivity

Human, Mouse

Application

WB ICC/IF

Conjugate

Unconjugated

Platform ID

BAB093067244

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameCaMKII alpha (phospho Thr286) antibody [HL3570]
Cat. No.GTX641517
Gene ID (Entrez)815
HostRabbit
IsotypeIgG
ReactivityHuman, Mouse
ConjugationUnconjugated
ApplicationWB ICC/IF
ClonalityMonoclonal
Concentration1 mg/ml (Please refer to the vial label for the specific concentration.)
TargetCAMK2A
ImmunogenCarrier-protein conjugated synthetic peptide surrounding phospho Thr286 of human CaMKII alpha. The exact sequence is proprietary.
PurityAffinity purified by Protein A.
Appearance/FormLiquid
FormulationPBS,No preservatives
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2018]

Synonyms

calcium/calmodulin dependent protein kinase II alpha , CAMKA , CaMKIINalpha , MRD53 , MRT63

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