Cadherin-17 (E5B1Y) Rabbit Monoclonal Antibody#88594,Cell Signaling Technology (CST),88594

Cadherin-17/Liver-Intestine-cadherin (CDH17/LI-cadherin) is a type-I transmembrane glycoprotein that belongs to the 7D-cadherin superfamily. Unlike classical cadherins, CDH17 is characterized by an extracellular domain with seven cadherin repeats and a short intracellular domain (1). CDH17 is a calcium-dependent homotypic cell-cell adhesion molecule that, under normal physiologic conditions in humans, is selectively expressed on the basolateral surface of epithelia lining the small intestine and colon (2). Research studies have demonstrated that CDH17 is aberrantly overexpressed in human gastric cancer and may serve as a novel oncogenic biomarker for this disease (3,4). At the molecular level, research studies have suggested that CDH17 exerts its oncogenicity in the context of gastric cancer through its ability to engage both NF-κB and MAPK signaling cascades (5,6).Berndorff, D. et al. (1994)J Cell Biol125, 1353-69.Gessner, R. and Tauber, R. (2000)Ann N Y Acad Sci915, 136-43.Grötzinger, C. et al. (2001)Gut49, 73-81.Dong, W. et al. (2007)Dig Dis Sci52, 536-42.Lin, Z. et al. (2014)PLoS One9, e85296.Wang, J. et al. (2013)Cancer Biol Ther14, 262-70.Alternate NamesCAD17; cadherin 17; cadherin 17, LI cadherin (liver-intestine); cadherin-16; Cadherin-17; CDH16; CDH17; FLJ26931; HPT-1; HPT-1 cadherin; HPT1; human intestinal peptide-associated transporter HPT-1; human peptide transporter 1; Intestinal peptide-associated transporter HPT-1; LI cadherin; LI-cadherin; Liver-intestine cadherin; MGC138218; MGC142024

CAD17; cadherin 17; cadherin 17, LI cadherin (liver-intestine); cadherin-16; Cadherin-17; CDH16; CDH17; FLJ26931; HPT-1; HPT-1 cadherin; HPT1; human intestinal peptide-associated transporter HPT-1; human peptide transporter 1; Intestinal peptide-associated transporter HPT-1; LI cadherin; LI-cadherin; Liver-intestine cadherin; MGC138218; MGC142024