Calnexin (C5C9) Rabbit Monoclonal Antibody (Alexa Fluor^®555 Conjugate)#23198,Cell Signaling Technology (CST),23198

Secretory and transmembrane proteins are synthesized on polysomes and translocate into the endoplasmic reticulum (ER) where they are often modified by the formation of disulfide bonds, amino-linked glycosylation and folding. To help proteins fold properly, the ER contains a pool of molecular chaperones including calnexin. Calnexin was first identified as being involved in the assembly of murine class I histocompatibility molecules (1,2). Calnexin is a calcium-binding protein embedded in the ER membrane that retains the newly synthesized glycoproteins inside the ER to ensure proper folding and quality control (3-5). The specificity of calnexin for a subset of glycoproteins is defined by a lectin site, which binds an early oligosaccharide intermediate on the folding glycoprotein (5).Degen, E. and Williams, D.B. (1991)J. Cell Biol.112, 1099-1115.Ahluwalia, N. et al. (1992)J. Biol. Chem.267, 10914-10918.Rajagopalan, S. et al. (1994)Science263, 387-390.Bergeron, J.J. et al. (1994)Trends Biochem. Sci.19, 124-128.Williams, D.B. (2006)J. Cell Sci.119, 615-623.Alternate NamesCalnexin; CALX; CANX; CNX; epididymis secretory sperm binding protein; FLJ26570; IP90; Major histocompatibility complex class I antigen-binding protein p88; p90

Calnexin; CALX; CANX; CNX; epididymis secretory sperm binding protein; FLJ26570; IP90; Major histocompatibility complex class I antigen-binding protein p88; p90