Cannabinoid Receptor 1 Downstream Signaling Antibody Sampler Kit#93521,Cell Signaling Technology (CST),93521

Cannabinoid receptors mediate a number of physiological processes in the brain ranging from appetite regulation, pain, learning, and memory (1). The major cannabinoid receptors in the brain include CB1 and CB2 receptors, which are G-protein coupled receptors (GPCRs).  CB1 interacts with other GPCRs including metabotropic glutamate receptor 1, mGluR1 (2). Endogenous ligands, endocannabinoids, but also exogenously introduced compounds such as tetrahydrocannabinol (THC), activate cannabinoid receptors by promoting the exchange of GDP for GTP, leading to a cascade of signaling pathways that are activated to drive various functions. Some of these functions include neurite outgrowth, inflammation, and transcriptional control (3). Components of this kit are readouts for several downstream signaling components of CB1 receptor and they can also be used as a readout for CB1 activation and function. Cannabinoid receptor function is not limited to brain function but may modulate peripheral functions, including immune responses (4,5).Smith, T.H. et al. (2010)Br J Pharmacol160, 454-66.Batista, E.M. et al. (2016)Mol Brain9, 80.Lu, D. et al. (2019)Acta Pharmacol Sin40, 324-35.Ruiz de Azua, I. et al. (2017)J Clin Invest127, 4148-62.Mehrpouya-Bahrami, P. et al. (2017)Sci Rep7, 15645.