Caspase 3 (CASP3) Antibody,Abbexa,abx034999
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly (ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, 7 and 9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
Host
Mouse
Reactivity
Human
Application
ELISA, WB
Conjugate
Unconjugated
Platform ID
BAB855094170
Abbexa
Contact
Tel: +44 (0) 1223 755950
Fax: +44 (0) 1223 755951
Email:
Product Specifications
Specifications
NameCaspase 3 (CASP3) Antibody
Cat. No.abx034999
Accession NumberP42574
HostMouse
IsotypeIgG1
ReactivityHuman
ConjugationUnconjugated
ApplicationELISA, WB
Working DilutionsWB: 1/2000. Optimal dilutions/concentrations should be determined by the end user.
ClonalityMonoclonal
Molecular WeightCalculated MW: 31.6 kDa
ImmunogenPurified His-tagged Human CASP3 protein
PurityPurified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Appearance/FormLiquid
FormulationPBS containing 0.09% sodium azide.
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Regulatory StatusResearch Use Only
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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