Caspase-3 Polyclonal Antibody,Bioss,bs-0081r-100ul

Host

Rabbit

Reactivity

Human, Mouse, Rat, Bovine, Pig, Chicken, Sheep, Rabbit, Others, Monkey

Application

WB, ELISA, IHC-P

Conjugate

Unconjugated

Platform ID

BAB162065143

Bioss

Headquarters

300 Tradecenter Dr, ste 4610Woburn, Massachusetts 01801 - U.S.A.

Bioss

Contact

Tel: +1.781.569.5821
Fax: +1.781.731.9286

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameCaspase-3 Polyclonal Antibody
Cat. No.bs-0081r-100ul
Accession NumberP42574
Gene ID (Entrez)836
HostRabbit
IsotypeIgG
ReactivityHuman, Mouse, Rat, Bovine, Pig, Chicken, Sheep, Rabbit, Others, Monkey
ConjugationUnconjugated
ApplicationWB, ELISA, IHC-P
Working DilutionsWB:1:300-5000 | ELISA:1:500-1000 | IHC-P:1:200-400
ClonalityPolyclonal
Concentration1ug/ul
PurityPurified by Protein A.
Formulation0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
StorageShipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

Scientific Background

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.

Synonyms

CPP32; SCA-1; CPP32B; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; CASP3

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