β-Catenin Rabbit pAb- ABclonal,ABclonal,A11932

Reactivity

Human, Mouse, Rat

Application

WB, IHC-P, IF/ICC, ELISA

Conjugate

Unconjugated

Platform ID

BAB181391035

ABclonal

Headquarters

500W Cummings Park, Ste. 6500 Woburn, MA 01801

ABclonal

Contact

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Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

Nameβ-Catenin Rabbit pAb- ABclonal
Cat. No.A11932
Accession NumberP35222
Gene ID (Entrez)1499
RRIDAB_2758875
IsotypeIgG
ReactivityHuman, Mouse, Rat
ConjugationUnconjugated
ApplicationWB, IHC-P, IF/ICC, ELISA
Working DilutionsWB:1:500 - 1:1000 | IHC-P:1:50 - 1:200 | IF/ICC:1:50 - 1:100 | ELISA:Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Molecular Weight100kDa
ImmunogenSynthetic peptide. This information is considered to be commercially sensitive.
PurityAffinity purification
Appearance/FormLiquid
StorageStore at -20℃. Avoid freeze / thaw cycles.; Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Regulatory StatusResearch Use Only

Scientific Background

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.

Synonyms

EVR7; CTNNB; MRD19; NEDSDV; armadillo; β-Catenin

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