Cathepsin Z (F4M4S) Rabbit Monoclonal Antibody#88297,Cell Signaling Technology (CST),88297

Cathepsin Z, also known as cathepsin X or cathepsin P, is a lysosomal cysteine proteinase member of the papain family encoded by theCTSZgene (1,2). It contains a uniquely short pro-domain containing an RGD integrin binding sequence, allowing functionality in cell adhesion, signaling, and extracellular matrix remodeling (3,4). Cathepsin Z is expressed in immune cells, specifically macrophages, monocytes, and dendritic cells, where it participates in several immune cell functions (5). It may play a role in tumorigenesis and has been implicated in several cancer types, including hepatocellular carcinoma, glioblastoma, non-small cell lung cancer, prostate cancer, and colorectal cancer (6-10). Cathepsin Z is also expressed and secreted by activated microglia in the brain and may play a role in neuroinflammation (11,12).Nägler, D.K. and Ménard, R. (1998)FEBS Lett434, 135-9.Nägler, D.K. et al. (1999)Biochemistry38, 12648-54.Lechner, A.M. et al. (2006)J Biol Chem281, 39588-97.Kos, J. et al. (2005)Exp Cell Res306, 103-13.Wang, J. et al. (2011)PLoS One6, e24967.Santamaría, I. et al. (1998)J Biol Chem273, 16816-23.Batista, A.A.S. et al. (2021)Braz J Med Biol Res54, e11439.Fang, Y. et al. (2019)Cancer Med8, 3544-3552.Wendt, W. et al. (2007)Exp Neurol204, 525-40.Hafner, A. et al. (2013)Aging Cell12, 604-14.Alternate Namescarboxypeptidase LB; cathepsin B2; cathepsin IV; Cathepsin P; Cathepsin X; cathepsin Y; Cathepsin Z; cathepsin Z1; CATZ; CTSX; CTSZ; cysteine-type carboxypeptidase; FLJ17088; lysosomal carboxypeptidase B; preprocathepsin P

carboxypeptidase LB; cathepsin B2; cathepsin IV; Cathepsin P; Cathepsin X; cathepsin Y; Cathepsin Z; cathepsin Z1; CATZ; CTSX; CTSZ; cysteine-type carboxypeptidase; FLJ17088; lysosomal carboxypeptidase B; preprocathepsin P