Centaurin gamma 1 (AGAP2) Rabbit Polyclonal Antibody,Medimabs,MM-0125

Host

Rabbit

Reactivity

Human

Application

IP, WB

Platform ID

BAB461977438

Medimabs

Headquarters

141 avenue du President-Kennedy 6th floor, Suite SB-6570 Montreal (Quebec) Canada, H2X 1Y4

Medimabs

Contact

Tel: 1 (514) 940-MABS (6227)
Fax: 1 (514) 733-1212

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameCentaurin gamma 1 (AGAP2) Rabbit Polyclonal Antibody
Cat. No.MM-0125
HostRabbit
SensitivityA specific antibody against the human centaurin gamma 1 protein (AGAP2).
ReactivityHuman
ApplicationIP, WB
Working DilutionsIf reconstituted with deionized water in 100 µL: WB: 1:200 (15 min at 37 ºC), or 1/5000 (incubation ON at 4 ºC); IP: native condition, 10 µL of serum per sample. Optimal dilution has to be determined by the user.
ClonalityPolyclonal
Clone Number---
TargetCentaurin gamma 1 (AGAP2)
Appearance/FormLyophilized serum
StorageLyophilized antibodies can be kept at 4ºC for up to 3 months and should be kept at -20ºC for long-term storage (2 years). To avoid freeze-thaw cycles, reconstituted antibodies should be aliquoted before freezing for long-term (1 year) storage (-80ºC) or kept at 4ºC for short-term usage (2 months). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made with the assay buffer. After the maximum long-term storage period (2 years lyophilized or 1 year reconstituted) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy. To limit antibody loss or degradation, BSA (final concentration 1%) and sodium azide (final concentration 0.02%) can be added to the suggested first dilution. It is important to first verify if those preservatives are compatible with your assay.
Regulatory StatusResearch Use Only

Scientific Background

Centaurins are a family of proteins that contain an Arf-GAP domain, ankyrin repeats and PH (pleckstrin homology). The human centaurin gamma subfamily is represented by three isoforms, centaurin gamma-1, centaurin gamma-2 and centaurin gamma-3, which are highly similar in primary structure. Centaurin gamma 1 is an enzyme that in humans is encoded by the AGAP2 gene and it is found mainly in the nucleus. It interacts with phosphoinositide 3-kinase regulatory subunit alpha (PIK3R1), Homer protein homolog 1 (Homer 1) and Band 4.1-like protein 1 (EPB41L1). Centaurin gamma 1 has been shown to be involved in small GTPase mediated signal transduction, regulation of ARF GTPase activity and negative regulation of neuron apoptosis.

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