Chk2 antibody [2F4],Genetex,GTX84685
Host
Mouse
Reactivity
Human, Mouse, Rat, Dog, Monkey
Application
WB ICC/IF FCM
Conjugate
Unconjugated
Platform ID
BAB384272456
Genetex
Contact
Tel: 1-949-553-1900
Fax: 1-949-309-2888
Email:
Product Specifications
Scientific Background
Synonyms
Specifications
NameChk2 antibody [2F4]
Cat. No.GTX84685
Gene ID (Entrez)11200
HostMouse
IsotypeIgG2b
ReactivityHuman, Mouse, Rat, Dog, Monkey
ConjugationUnconjugated
ApplicationWB ICC/IF FCM
ClonalityMonoclonal
Concentration1.2 mg/ml (Please refer to the vial label for the specific concentration.)
TargetCHEK2
ImmunogenFull length human recombinant protein of human CHEK2 (NP_009125) produced in HEK293T cell.
PurityPurified by affinity chromatography
Appearance/FormLiquid
FormulationPBS, 1% BSA, 50% Glycerol,0.02% Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only
Scientific Background
Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on 'Ser-216', preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at 'Thr-18' and 'Ser-20'.
Synonyms
checkpoint kinase 2 , CDS1 , CHK2 , HuCds1 , LFS2 , PP1425 , RAD53 , hCds1
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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