Cleaved-Caspase 3 p12 Rabbit mAb,ABclonal,A28349
Reactivity
Human
Application
WB, ELISA
Conjugate
Unconjugated
Platform ID
BAB926968159
ABclonal
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Product Specifications
Scientific Background
Synonyms
Specifications
NameCleaved-Caspase 3 p12 Rabbit mAb
Cat. No.A28349
Accession NumberP42574
Gene ID (Entrez)836
IsotypeIgG
ReactivityHuman
ConjugationUnconjugated
ApplicationWB, ELISA
Working DilutionsWB:1:2000 - 1:10000 | ELISA:Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements. For high-ratio antibody dilutions (≥1:10000)，a sequential dilution method is strongly recommended to ensure measurement accuracy.
Clone NumberARC77461
Molecular Weight12 kDa
ImmunogenSynthetic peptide. This information is considered to be commercially sensitive.
PurityAffinity purification
Appearance/FormLiquid
StorageStore at -20℃. Avoid freeze / thaw cycles.; Buffer: PBS with 0.09% Sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Regulatory StatusResearch Use Only
Scientific Background
The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.
Synonyms
CPP32; SCA-1; CPP32B
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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