CoREST Antibody (YA1813),MedChemexpress,HY-P82068

CoREST is an essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited to RE1/NRSE sites by REST and functions by deacetylating and demethylating specific histone sites, acting as a chromatin modifier. Within the BHC complex, CoREST serves as a molecular beacon for recruiting silencing machinery, including MeCP2 and SUV39H1, to impose silencing across chromosomal intervals. It plays a central role in demethylating histone H3 at Lys-4 by enhancing the demethylase activity of KDM1A on core histones and nucleosomal substrates while protecting KDM1A from proteasomal degradation. CoREST is also part of the RCOR/GFI/KDM1A/HDAC complex, which suppresses genes involved in multilineage blood cell development through histone deacetylase (HDAC) recruitment and regulates hematopoietic differentiation.

COREST; Nr2b2; RCOR; Rcor1; Rxrb