Connexin Antibody Explorer Kit,Alomone Labs,AK-420_KIT

Connexins (Cx) are integral membrane proteins consisting of four transmembrane domains, two extracellular loops, one intracellular loop and intracellular N- and C-termini. The 21 members belonging to this family form homomeric or heteromeric hexamers generally termed connexons or hemi-channels. In turn, these hemi-channels further assemble in a head-to-head manner, thus forming gap junction channels 1,2 . Connexins are ubiquitously expressed and their activity is regulated at the expression level and by post-translational modifications 1 . For example, Connexin-43 (Cx43) protein level is regulated by its turnover rate and by phosphorylation of various residues which ultimately determines its activity rate 1 .