Cyclin A2 (E1D9T) Rabbit Monoclonal Antibody#91500,Cell Signaling Technology (CST),91500

Cyclin A2 (E1D9T) Rabbit Monoclonal Antibody recognizes endogenous levels of total Cyclin A2 protein.

Host

Rabbit

Reactivity

Human

Application

Western Blotting: 1:1000 Simple WesternTM: 1:10 - 1:50

Platform ID

BAB285241163

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameCyclin A2 (E1D9T) Rabbit Monoclonal Antibody#91500
Cat. No.91500
Accession NumberP20248
Gene ID (Entrez)20248
HostRabbit
SensitivityEndogenous
ReactivityHuman
ApplicationWestern Blotting: 1:1000 Simple WesternTM: 1:10 - 1:50
Molecular Weight55
ImmunogenIgG
FormulationSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
StorageSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Regulatory StatusResearch Use Only

Scientific Background

While overcoming the G1/S checkpoint to commence DNA replication requires cyclin E, and traversing the G2/M checkpoint to initiate mitosis requires cyclin B to be present, cyclin A seems to be required for both S-phase and M-phase (1). A number of studies have described the ability of overexpressed cyclin A to accelerate the G1 to S transition, causing DNA replication, and cyclin A antisense DNA can prevent DNA replication (2-4). Cyclin A availability is apparently the rate-limiting step for entry into mitosis, and cyclin A is required for the completion of prophase (5). At late prophase, cyclin A may no longer be necessary as cdc2/cyclinB1 becomes active (5).Pagano, M. et al. (1992)EMBO. J.11, 961-71.Resnitzky, D. et al. (1995)Mol. Cell. Biol.15, 4347-52.d'Urso, G. et al. (1990)Science250, 786-91.Zindy, F. et al. (1992)Biochem. Biophys. Res. Commun.182, 1144-54.Furuno, N. et al. (1999)J. Cell. Biol.147, 295-306.Alternate NamesCCN1; CCNA; CCNA2; Cyclin A; cyclin A2; Cyclin-A; Cyclin-A2

Synonyms

CCN1; CCNA; CCNA2; Cyclin A; cyclin A2; Cyclin-A; Cyclin-A2

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