Cyclin D1 antibody [DCS-6],Genetex,GTX10540

Host

Mouse

Reactivity

Human, Mouse, Rat, Monkey

Application

WB ICC/IF IHC-P IHC-Fr IP

Conjugate

Unconjugated

Platform ID

BAB054508290

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameCyclin D1 antibody [DCS-6]
Cat. No.GTX10540
Gene ID (Entrez)595
HostMouse
IsotypeIgG2a
ReactivityHuman, Mouse, Rat, Monkey
ConjugationUnconjugated
ApplicationWB ICC/IF IHC-P IHC-Fr IP
ClonalityMonoclonal
TargetCCND1
Immunogenrecombinant human Cyclin D1 protein.
PurityUnpurified
Appearance/FormLiquid
FormulationAscites,15mM Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

During each cell cycle cyclins undergo periodic accumulation and destruction. As key regulators of the cell cycle the cyclins control important transitions by activating Cdks. Early in the G1 phase of the cell cycle cyclin D1 induction is followed by cyclin E induction. This sequential progression is marked early on in G1 by the activation of Cdk4 and in mid to late G1 by the activation of Cdk2 and the hyperphosphorylation of pRB. The final transition into S phase is thought to be dependent on the increased expression and association of cyclin E and Cdk2.

Synonyms

cyclin D1 , BCL1 , D11S287E , PRAD1 , U21B31

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