Cyclin E antibody [168],Genetex,GTX16122
Host
Mouse
Reactivity
Human, Monkey
Application
WB IP
Conjugate
Unconjugated
Platform ID
BAB978922060
Genetex
Contact
Tel: 1-949-553-1900
Fax: 1-949-309-2888
Email:
Product Specifications
Scientific Background
Specifications
NameCyclin E antibody [168]
Cat. No.GTX16122
HostMouse
IsotypeIgG2a
ReactivityHuman, Monkey
ConjugationUnconjugated
ApplicationWB IP
ClonalityMonoclonal
Concentration1 mg/ml (Please refer to the vial label for the specific concentration.)
ImmunogenRecombinant full length protein (Human).
PurityThis antibody is provided as a 0.2 μm sterile filtered solution.
Appearance/FormLiquid
FormulationPBS,0.08% Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only
Scientific Background
Cyclin E is a regulatory subunit of Cdk2 and controls G1 / S transition during the mammalian cell cycle. Multiple isoforms of Cyclin E are expressed only in tumors but not in the normal tissues, suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in Cyclin E protein have been implicated as indicators of worse prognosis in various cancers.
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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