DARC Antibody (YA1654),MedChemexpress,HY-P81909

DARC is an atypical chemokine receptor that regulates chemokine levels and localization through high-affinity binding, uncoupled from classical ligand-driven signal transduction, leading to chemokine sequestration, degradation, or transcytosis. Also known as an interceptor (internalizing receptor), chemokine-scavenging receptor, or chemokine decoy receptor, it exhibits a promiscuous binding profile, interacting with inflammatory chemokines from both CXC and CC subfamilies but not homeostatic chemokines. It serves as a receptor for chemokines such as CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, and TARC. DARC modulates chemokine bioavailability and leukocyte recruitment via two mechanisms: in endothelial cells, it facilitates transcytosis of tissue-derived chemokines for presentation to leukocytes; in erythrocytes, it acts as a chemokine reservoir and sink to buffer plasma chemokine surges. Additionally, DARC functions as a receptor for the malaria parasites Plasmodium vivax and Plasmodium knowlesi.

CCBP1; CD234; DARC; Dfy; FY; GPD; GpFy; WBCQ1