DCLK1/DCAMKL1 (D2U3L) Rabbit Monoclonal Antibody#62257,Cell Signaling Technology (CST),62257

Doublecortin-like kinase 1 (DCLK1, DCAMKL1) is a serine/threonine kinase that belongs to the CaM kinase family and shares homology with the neuronal microtubule binding protein doublecortin. DCLK1 is thought to be involved in calcium signaling pathways controlling neuronal development in the embryonic brain (1,2). The kinase also functions in the mature nervous system and is highly expressed in regions of active neurogenesis in the neocortex and cerebellum (3,4). Research studies suggest that the DCLK1 kinase is highly expressed in subpopulations of cells within the colon and gastric epithelium and in the pancreas (5-8). The nature of these cell populations, whether normal, stem-like, or tumor-initiating, is unclear.Burgess, H.A. et al. (1999)J Neurosci Res58, 567-75.Tanaka, T. et al. (2006)Cereb Cortex16 Suppl 1, i69-73.Shin, E. et al. (2013)Nat Commun4, 1440.Saaltink, D.J. et al. (2012)J Comp Neurol520, 2805-23.May, R. et al. (2009)Stem Cells27, 2571-9.May, R. et al. (2010)Am J Physiol Gastrointest Liver Physiol299, G303-10.Saqui-Salces, M. et al. (2011)Histochem Cell Biol136, 191-204.Qu, D. et al. (2014)Am J Physiol Gastrointest Liver Physiol306, G404-11.Alternate NamesCL1; CLICK1; DCAMKL1; DCDC3A; DCLK; DCLK1; doublecortin and CaM kinase-like 1; Doublecortin domain-containing protein 3A; doublecortin like kinase 1; Doublecortin-like and CAM kinase-like 1; Doublecortin-like kinase 1; KIAA0369; Serine/threonine-protein kinase DCLK1

CL1; CLICK1; DCAMKL1; DCDC3A; DCLK; DCLK1; doublecortin and CaM kinase-like 1; Doublecortin domain-containing protein 3A; doublecortin like kinase 1; Doublecortin-like and CAM kinase-like 1; Doublecortin-like kinase 1; KIAA0369; Serine/threonine-protein kinase DCLK1