DMAP1 Antibody (YA2998),MedChemexpress,HY-P83253

DMAP1 is a protein involved in both transcriptional repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following DNA replication at late firing origins. It can repress transcription independently of histone deacetylase activity and may specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. As a component of the NuA4 histone acetyltransferase (HAT) complex, this complex activates transcription of select genes primarily through acetylation of nucleosomal histones H4 and H2A. This modification can alter nucleosome-DNA interactions while promoting interaction between modified histones and other transcription-promoting proteins. The complex is implicated in activating transcriptional programs related to oncogene/proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest, replicative senescence, apoptosis, and DNA repair. When recruited to DNA damage sites, NuA4 may directly participate in DNA repair processes. Additionally, DMAP1 contributes to the nuclear localization of URI1 and enhances its transcriptional corepressor activity.

DNA methyltransferase 1 associated protein 1; DNMAP1; DNMTAP1; EAF2; SWC4