DNA Polymerase beta Antibody (YA3378),MedChemexpress,HY-P83633

DNA Polymerase beta is a repair polymerase that plays a key role in base-excision repair (BER). During this process, the damaged base is excised by specific DNA glycosylases, the DNA backbone is nicked at the abasic site by an apurinic/apyrimidic (AP) endonuclease, and POLB removes 5'-deoxyribose-phosphate from the preincised AP site, acting as a 5'-deoxyribose-phosphate lyase (5'-dRP lyase). Through its DNA polymerase activity, it adds one nucleotide to the 3' end of the resulting single-nucleotide gap. It conducts 'gap-filling' DNA synthesis in a stepwise distributive manner rather than the processive fashion typical of other DNA polymerases. Additionally, it can cleave sugar-phosphate bonds 3' to an intact AP site, functioning as an AP lyase. (by similar: cleaves sugar-phosphate bonds 3' to an intact AP site)

POLB; DNA polymerase beta