DYRK2 (D9A3K) Rabbit Monoclonal Antibody#11921,Cell Signaling Technology (CST),11921

The DYRK family includes severaldual-specificity tyrosine-phosphorylated andregulatedkinases capable of phosphorylating proteins at both Tyr and Ser/Thr residues (1). The DYRK family was identified based on homology to the yeast Yak1 (2) and theDrosophilaminibrain (mnb) kinases (3). Seven mammalian isoforms have been discovered, including DYRK1A, DYRK1B, DYRK1C, DYRK2, DYRK3, DYRK4, and DYRK4B. Differences in substrate specificity, expression, and subcellular localization are seen across the DYRK family (4,5). All DYRK proteins have a Tyr-X-Tyr motif in the catalytic domain activation loop; phosphorylation of the second Tyr residue (e.g. Tyr312 of DYRK1A) is necessary for kinase activity. DYRKs typically autophosphorylate the Tyr residue within their activation loop, but phosphorylate substrates at Ser and Thr residues (1,6).DYRK2 is thought to play a role in checkpoint control of the cell cycle. DYRK2 can phosphorylate p53 at Ser46 following cellular damage, leading to activation of the apoptotic response (7). Research studies have demonstrated overexpression of DYRK2 in esophageal and lung adenocarcinomas (8), with DYRK2 expression levels acting as a potential predictor of chemotherapy treatment outcomes in non-small cell lung cancer (9).Becker, W. and Joost, H.G. (1999)Prog. Nucleic Acid Res. Mol. Biol.62, 1-17.Garrett, S. and Broach, J. (1989)Genes Dev.3, 1336-1348.Tejedor, F. et al. (1995)Neuron14, 287-301.Kentrup, H. et al. (1996)J. Biol. Chem.271, 3488-3495.Becker, W. et al. (1998)J. Biol. Chem.273, 25893-25902.Lochhead, P.A. et al. (2005)Cell121, 925-936.Taira, N. et al. (2007)Mol Cell25, 725-38.Miller, C.T. et al. (2003)Cancer Res63, 4136-43.Yamashita, S. et al. (2009)Anticancer Res29, 2753-7.Alternate Namesdual specificity tyrosine phosphorylation regulated kinase 2; dual specificity tyrosine-(Y)-phosphorylation regulated kinase 2; Dual specificity tyrosine-phosphorylation-regulated kinase 2; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2; DYRK2; FLJ21217; FLJ21365

dual specificity tyrosine phosphorylation regulated kinase 2; dual specificity tyrosine-(Y)-phosphorylation regulated kinase 2; Dual specificity tyrosine-phosphorylation-regulated kinase 2; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2; DYRK2; FLJ21217; FLJ21365