Drosha Antibody (YA472),MedChemexpress,HY-P80110

Drosha is a double-stranded (ds) RNA-specific endoribonuclease (Ribonuclease III) involved in the initial step of microRNA (miRNA) biogenesis. As a core component of the microprocessor complex, Drosha processes primary miRNA transcripts (pri-miRNAs) in the nucleus to release precursor miRNAs (pre-miRNAs). Within this complex, Drosha cleaves both the 3' and 5' strands of pri-miRNA stem-loops (11 bp from the dsRNA-ssRNA junction) to generate hairpin-shaped pre-miRNAs, which are subsequently processed by cytoplasmic DICER into mature miRNAs. It also participates in pre-rRNA processing, specifically cleaving dsRNA while avoiding ssRNA, and contributes to GW body formation. By similarity, Drosha plays a role in growth homeostasis regulation through autophagy responses in motor neurons.