EXOSC6 antibody, N-term,Genetex,GTX47229

Host

Rabbit

Reactivity

Human

Application

WB IHC-P

Conjugate

Unconjugated

Platform ID

BAB608820943

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameEXOSC6 antibody, N-term
Cat. No.GTX47229
Gene ID (Entrez)118460
HostRabbit
IsotypeIgG
ReactivityHuman
ConjugationUnconjugated
ApplicationWB IHC-P
ClonalityPolyclonal
Concentration0.5-1 mg/ml (Please refer to the vial label for the specific concentration.)
TargetEXOSC6
ImmunogenA synthetic peptide corresponding to a N-terminal region of Human EXOSC6
PurityProtein A purified
Appearance/FormLiquid
FormulationPBS, 2% Sucrose,0.09% Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation. [provided by RefSeq, Jul 2008]

Synonyms

exosome component 6 , EAP4 , MTR3 , Mtr3p , hMtr3p , p11

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