Eosinophil peroxidase (F4O7J) Rabbit Monoclonal Antibody (BSA and Azide Free)#69487,Cell Signaling Technology (CST),69487

Eosinophil peroxidase (EPX), also known as EPO, is a cationic protein stored in the secondary granulocytes of eosinophils (1-4). Unprocessed precursor EPX is an 80 kDa monomeric glycoprotein, which consists of two polypeptides linked by disulfide bonds: ~55 kDa heavy and ~15 kDa light chain (1-3, 6). In response to allergens or parasitic infection, eosinophils are recruited to affected tissues, where EPX catalyzes the formation of reactive oxidants lethal to tissue-invading parasites (1-4). In the tumor microenvironment of some breast cancers, eosinophils accumulate near blood vessels and infiltrate hypoxic regions, where EPX is released in high quantities by infiltrating immune cells (5). EPX may contribute to cancer progression by augmenting pro-tumorigenic collagen production and angiogenesis, making it a potential therapeutic target in breast cancer therapy (5).Peterson, C.G. and Venge, P. (1983)Immunology50, 19-26.Ten, R.M. et al. (1989)J Exp Med169, 1757-69.Larson, K.A. et al. (1995)J Immunol155, 3002-12.Doyle, A.D. et al. (2013)Blood122, 781-90.Panagopoulos, V. et al. (2017)Int J Oncol50, 1191-1200.Pfanzagl, V. et al. (2023)J Biol Chem299, 105402.Alternate NamesEosinophil peroxidase; Eosinophil peroxidase heavy chain; Eosinophil peroxidase light chain; EPER; EPO; EPP; EPX; EPX-PEN; EPXD; PERE

Eosinophil peroxidase; Eosinophil peroxidase heavy chain; Eosinophil peroxidase light chain; EPER; EPO; EPP; EPX; EPX-PEN; EPXD; PERE