FAK (F7Z4C) Mouse Monoclonal Antibody (BSA and Azide Free)#87095,Cell Signaling Technology (CST),87095

Focal adhesion kinase (FAK) is a widely expressed cytoplasmic protein tyrosine kinase involved in integrin-mediated signal transduction. It plays an important role in the control of several biological processes, including cell spreading, migration, and survival (1). Activation of FAK by integrin clustering leads to autophosphorylation at Tyr397, which is a binding site for the Src family kinases PI3K and PLCγ (2-5). Recruitment of Src family kinases results in the phosphorylation of Tyr407, Tyr576, and Tyr577 in the catalytic domain, and Tyr871 and Tyr925 in the carboxy-terminal region of FAK (6,7).Parsons, J.T. et al. (2000)Oncogene19, 5606-13.Schaller, M.D. et al. (1994)Mol Cell Biol14, 1680-8.Cobb, B.S. et al. (1994)Mol Cell Biol14, 147-55.Chen, H.C. et al. (1996)J Biol Chem271, 26329-34.Zhang, X. et al. (1999)Proc Natl Acad Sci U S A96, 9021-6.Calalb, M.B. et al. (1995)Mol Cell Biol15, 954-63.Schlaepfer, D.D. et al. (1994)Nature372, 786-791.Alternate NamesFADK; FADK 1; FAK; FAK-related non-kinase polypeptide; FAK1; Focal adhesion kinase 1; Focal adhesion kinase-related nonkinase; FRNK; p125FAK; pp125FAK; PPP1R71; Protein phosphatase 1 regulatory subunit 71; protein tyrosine kinase 2; Protein-tyrosine kinase 2; PTK2; PTK2 protein tyrosine kinase 2

FADK; FADK 1; FAK; FAK-related non-kinase polypeptide; FAK1; Focal adhesion kinase 1; Focal adhesion kinase-related nonkinase; FRNK; p125FAK; pp125FAK; PPP1R71; Protein phosphatase 1 regulatory subunit 71; protein tyrosine kinase 2; Protein-tyrosine kinase 2; PTK2; PTK2 protein tyrosine kinase 2