FAK (phospho Tyr576) antibody,Genetex,GTX24815

Host

Rabbit

Reactivity

Human, Mouse, Xenopus laevis

Application

WB

Conjugate

Unconjugated

Platform ID

BAB740691408

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Product Specifications
Scientific Background
Synonyms

Specifications

NameFAK (phospho Tyr576) antibody
Cat. No.GTX24815
Gene ID (Entrez)5747
HostRabbit
IsotypeIgG
ReactivityHuman, Mouse, Xenopus laevis
ConjugationUnconjugated
ApplicationWB
ClonalityPolyclonal
Concentration0.5 mg/ml (Please refer to the vial label for the specific concentration.)
TargetPTK2
ImmunogenSynthetic peptide (Human) derived from the region of human Focal Adhesion Kinase that contains tyrosine 576. The sequence is conserved in mouse, rat, chicken and frog.
PurityImmunogen affinity purifiedPurified from rabbit serum by sequential epitope-specific chromatography. The antibody has been negatively preadsorbed using (i) a non-phosphopeptide corresponding to the site of phosphorylation to remove antibody that is reactive with non-phosphorylated
Appearance/FormLiquid
FormulationPBS, 0.1% BSA,0.05% Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]

Synonyms

protein tyrosine kinase 2 , FADK , FAK , FAK1 , FRNK , PPP1R71 , p125FAK , pp125FAK

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