FAM3C (D1S2D) Rabbit Monoclonal Antibody#15171,Cell Signaling Technology (CST),15171

FAM3C, also known as ILEI (interleukin-like epithelial-to-mesenchymal transition [EMT] inducer), is a cytokine-like protein and member of the FAM3 family. FAM3C plays an important role in EMT and metastasis during cancer progression in human and mouse cells, and is highly expressed in human cancer (1,2). In colorectal cancer, researchers have indicated that FAM3C is a marker for EMT and tumor progression, and that high expression of FAM3C is predictive of poor prognosis (3). While EMT induction by FAM3C can be independent of TGF-beta, research studies have also shown TGF-beta-dependent regulation of FAM3C expression at the translational level in mouse and human cells (4,5).FAM3C has also been linked to regulation of osteoblast differentiation (6), and to accumulation of amyloid beta plaques in Alzheimer’s disease (7). FAM3C exists in monomeric and in homodimeric form, and research shows that FAM3C homodimers contain its EMT-inducing and tumor promoting activity (8).Waerner, T. et al. (2006)Cancer Cell10, 227-39.Lahsnig, C. et al. (2009)Oncogene28, 638-50.Gao, Z.H. et al. (2014)Histopathology65, 527-38.Chaudhury, A. et al. (2010)Nat Cell Biol12, 286-93.Song, Q. et al. (2014)Tumour Biol35, 1377-82.Bendre, A. et al.Differentiation93, 50-57.Liu, L. et al. (2016)Neuroscience330, 236-46.Kral, M. et al. (2017)FEBS J284, 3484-3505.Alternate NamesFAM3 metabolism regulating signaling molecule C; FAM3C; family with sequence similarity 3 member C; family with sequence similarity 3, member C; GS3786; ILEI; interleukin-like EMT inducer; interleukin-like epithelial-mesenchymal transition inducer; predicted osteoblast protein; Protein FAM3C

FAM3 metabolism regulating signaling molecule C; FAM3C; family with sequence similarity 3 member C; family with sequence similarity 3, member C; GS3786; ILEI; interleukin-like EMT inducer; interleukin-like epithelial-mesenchymal transition inducer; predicted osteoblast protein; Protein FAM3C