FE65 antibody,Genetex,GTX25668

The major transcript of the Fe65 gene is a neuron-specific mRNA that encodes a nuclear protein whose amino-terminal domain strongly activates the transcription of reporter genes. Fe65 has been implicated in a regulatory and cell signaling mechanism because it contains two different motifs involved in protein binding; a WW domain (a variant of Src homology 3 domains) and a phosphotyrosine interaction domain (PID). Interestingly, the PID domain binds to the same motif present in the conserved cytoplasmic domains of the beta PP and beta PP-like proteins. RNA analyses revealed that Fe65 is predominantly expressed in the brain and in the regions most affected by Alzheimer’s disease-associated neuropathology.

amyloid beta (A4) precursor protein-binding, family B, member 1 , Fe65 , Rir